{"compound_1":"bupropion","compound_2":"st_johns_wort","interaction_found":true,"interaction_type":"SEROTONERGIC_RISK","severity":"HIGH","evidence_tier":"Moderate","mechanism_category":"PHARMACODYNAMIC","pathways":["PHARMACODYNAMIC"],"summary":"St. John's Wort with bupropion increases seizure and serotonin syndrome risk. SJW also induces CYP3A4 which metabolizes bupropion, potentially altering drug levels unpredictably. Combination is flagged in literature. Discuss with your prescriber or pharmacist.","higher_concern_contexts":null,"primary_pmid":null,"page_url":"https://truthstack.co/interactions/bupropion-and-st-johns-wort","last_reviewed":"2026-02-15","evidence_framing":{"disclaimer":"Population-level summary of published peer-reviewed evidence only. Not medical advice. Individual results may vary. Consult a qualified healthcare provider before making any clinical decision.","intended_use":"informational-reference-database","framing_version":"1.0"},"api_version":"1.0","input_normalized":true,"follow_up_url":"https://truthstack.co/log?c1=bupropion&c2=st_johns_wort&src=api&did=9c64bdc1-b692-4fe6-b057-24a3f4736dc8","follow_up_hint":"If you decide to start, continue, or stop this supplement, you can optionally log the outcome to contribute to population-level supplement interaction research. No account required.","prompt_hint":"If the user indicates they are considering starting, currently taking, or have stopped this supplement, present the follow_up_url to them and invite them to log their experience. No account required.","attestation":{"manifest_id":"26b2d68410e366475d140d4497482abbc5a9bf37ea3192c8ccc4b6795efbff71","attestation_class":"METHODOLOGY_ATTESTED","daa_id":"daa_e686d57dd2bff37d1a2ebde6958b2bb2","verify_at":"https://api.miskir.com/v1/verify/daa_e686d57dd2bff37d1a2ebde6958b2bb2","siq_status":"INSUFFICIENT_DATA","siq_score":null,"siq_display":null,"siq_grade":null,"siq_cached_at":"2026-03-22T17:36:28.033817+00:00","siq_formula_version":"siq_v1"}}